Resveratrol Human Clinical Trials Begin

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With massive media exposure, from television interviews with Barbara Walters and 60 Minutes to articles published in the New York Times, resveratrol is the most highly anticipated anti-aging supplement currently in development.

Resveratrol (trans-resveratrol) is a compound jammed packed with beneficial antioxidants. It is found naturally in various plants, but higher concentrations of it were recently found in red wine, which is fermented with the skins of grapes.

For decades, we’ve known that there was something beneficial about red wine, but scientists were never able to figure out why. Back in 1991, 60 Minutes labeled this mystery the “French Paradox,” which described the unlikely relationship between the fact that while the French enjoy diets high in saturated fats, they oddly have one of the lowest rates of heart disease in the world.

It wasn’t until 2007, when Dr. David A. Sinclair of the Harvard Medical School discovered the benefits of resveratrol, that the French Paradox mystery was finally solved. Dr. Sinclair found that in high doses the resveratrol molecule activates the body’s natural anti-aging gene, called Sirtuin 1.

As a result, resveratrol as a supplement has shown incredible potential for preventing all types of age-related problems and even the possibility for extending the human lifespan. In one lab test, two groups of mice were fed the same high fat diets but the mice who were also given resveratrol ran twice as far, lived 30% longer and none of them got heart disease, diabetes, cancer or osteoporosis.

Whether or not resveratrol will have similar benefits on humans is yet to be discovered in the clinical trials which have just begun. However, scientists have long known an already proven method for living longer and preventing age-related diseases. A dietary regimen called caloric restriction has been well documented to increase both the median and maximum lifespan of humans. In spite of this, most people choose to forgo it because caloric restriction is extremely rigorous and unpleasant to keep up.

Nonetheless, if human trials of resveratrol do prove to be successful, we may all soon be enjoying the benefits of caloric restriction without having to change our diets. And if it does increase our healthy lifespan, many of us could be in our 80s yet behaving as if we were in our 50s.

Warning Regarding Resveratrol Supplements Already on the Market

With all the hype about resveratrol, many companies are trying to capitalize on it and are already getting supplements to the market. If you are considering purchasing resveratrol it is important to keep in mind three things:

  1. Until the human clinical trials are complete, there is no concrete evidence that resveratrol will have the same effects on humans as it has on mice.

  2. Not all resveratrol supplements are trans-resveratrol or the same strength. To get the maximum potential benefits, you want to make sure it specifically says trans-resveratrol and look for the highest dosage possible.

  3. Watch out for scams. Some companies are re-labeling red wine extract and trying to pass it off as resveratrol. Also, keep in mind that any company offering a free trial will automatically bill you if you do not cancel within the trial term. Always carefully read the terms and conditions for any offer that seems to good to be true.

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